| Identification | Back Directory | [Name]
AZ-3 | [CAS]
2228908-91-4 | [Synonyms]
AZ-3
2,4-Pyrimidinediamine, N2-[2-fluoro-5-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-3-pyridinyl]-5-methyl-N4-[(1R)-1-methylpropyl]- | [Molecular Formula]
C20H28FN7 | [MDL Number]
MFCD31813676 | [MOL File]
2228908-91-4.mol | [Molecular Weight]
385.48 |
| Hazard Information | Back Directory | [Uses]
AZ-3 is a potent and selective JAK1 inhibitor with an IC50 of 34 nM. | [References]
[1] Grimster NP, et al. Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors. J Med Chem. 2018 Jun 28;61(12):5235-5244. DOI:10.1021/acs.jmedchem.8b00076 |
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