| Identification | Back Directory | [Name]
1,1-Dimethylethyl 4-[[1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-4-piperidinyl]methyl]-1-piperazinecarboxylate | [CAS]
2229725-33-9 | [Synonyms]
E3 Ligase Ligand-linker Conjugate 54
1,1-Dimethylethyl 4-[[1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-4-piperidinyl]methyl]-1-piperazinecarboxylate | [Molecular Formula]
C28H37N5O6 | [MOL File]
2229725-33-9.mol | [Molecular Weight]
539.62 |
| Chemical Properties | Back Directory | [Boiling point ]
733.9±60.0 °C(Predicted) | [density ]
1.305±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
10.83±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
E3 Ligase Ligand-linker Conjugate 54 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 54 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules. | [References]
[1] Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. DOI:10.1038/nature13527
[2] Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203. DOI:10.12659/MSM.909977
[3] Bian C, et al. Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down-regulation of TGF-β/Smad3 signaling pathway in an Nrf2-dependent manner. Free Radic Biol Med. 2018 Dec;129:446-453. DOI:10.1016/j.freeradbiomed.2018.10.423 |
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| Company Name: |
Pharmalego
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| Telephone: |
18321033991 |
| Website: |
https://cn.pharmalego.com/ |
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