2245697-87-2

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2245697-87-2 Structure

Identification	Back Directory
[Name] Thalidomide-NH-PEG2-C2-NH2 hydrochloride
[CAS] 2245697-87-2
[Synonyms] -PEG2-amine Pomalidomide 4&rsquo Thalidomide-NH-PEG2-NH2 HCl Thalidomide-NH-PEG2-C2-NH2 hydrochloride Pomalidomide-NH-PEG2-amine hydrochloride
[Molecular Formula] C19H25ClN4O6
[MDL Number] MFCD31689260
[MOL File] 2245697-87-2.mol
[Molecular Weight] 440.88

Chemical Properties	Back Directory
[storage temp. ] Store at -20°C
[solubility ] Soluble in DMSO
[form ] Solid
[color ] Light yellow to green yellow

Hazard Information	Back Directory
[Uses] Thalidomide-PEG2-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].
[IC 50] Cereblon
[storage] Store at -20°C
[References] [1] Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163. DOI:10.1021/acs.jmedchem.9b00919

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