| Identification | Back Directory | [Name]
Thalidomide-NH-PEG2-C2-NH2 hydrochloride | [CAS]
2245697-87-2 | [Synonyms]
-PEG2-amine
Pomalidomide 4&rsquo
Thalidomide-NH-PEG2-NH2 HCl
Thalidomide-NH-PEG2-C2-NH2 hydrochloride
Pomalidomide-NH-PEG2-amine hydrochloride | [Molecular Formula]
C19H25ClN4O6 | [MDL Number]
MFCD31689260 | [MOL File]
2245697-87-2.mol | [Molecular Weight]
440.88 |
| Hazard Information | Back Directory | [Uses]
Thalidomide-PEG2-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1]. | [IC 50]
Cereblon | [storage]
Store at -20°C | [References]
[1] Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163. DOI:10.1021/acs.jmedchem.9b00919 |
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