| Identification | Back Directory | [Name]
CCT-367766 | [CAS]
2229856-58-8 | [Synonyms]
CCT-367766
6-Quinolinecarboxamide, N-[2-chloro-5-[[(2,3-dihydro-1,4-benzodioxin-6-yl)carbonyl]amino]phenyl]-2-[[4-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethoxy]ethoxy]ethyl]-1-piperazinyl]methyl]- | [Molecular Formula]
C49H48ClN7O11 | [MDL Number]
MFCD31812776 | [MOL File]
2229856-58-8.mol | [Molecular Weight]
946.4 |
| Hazard Information | Back Directory | [Uses]
CCT367766 is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 provides a potential chemical tool to study a largely unexplored protein[1]. | [IC 50]
CRBN-DDB1: 490 nM (IC50) | [References]
[1] Chessum NEA, et al. Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).J Med Chem.?2018 Feb 8;61(3):918-933. DOI:10.1021/acs.jmedchem.7b01406 |
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| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
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