| Identification | Back Directory | [Name]
1H-Pyrazole-4-carboxamide, 1-(1,2-dihydro-1-oxo-5-isoquinolinyl)-5-(trifluoromethyl)-N-[2-(trifluoromethyl)-4-pyridinyl]- | [CAS]
2230273-76-2 | [Synonyms]
JNJ-67856633
1-(1-oxo-1,2-dihydroisoquinolin-5-yl)-5-(trifluoromethyl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-pyrazole-4-carboxamide
1H-Pyrazole-4-carboxamide, 1-(1,2-dihydro-1-oxo-5-isoquinolinyl)-5-(trifluoromethyl)-N-[2-(trifluoromethyl)-4-pyridinyl]- | [Molecular Formula]
C20H11F6N5O2 | [MDL Number]
MFCD34475932 | [MOL File]
2230273-76-2.mol | [Molecular Weight]
467.32 |
| Chemical Properties | Back Directory | [Boiling point ]
570.0±50.0 °C(Predicted) | [density ]
1.59±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (267.48 mM; Need ultrasonic) | [form ]
Solid | [pka]
11.01±0.70(Predicted) | [color ]
Off-white to yellow | [InChI]
InChI=1S/C20H11F6N5O2/c21-19(22,23)15-8-10(4-6-27-15)30-18(33)13-9-29-31(16(13)20(24,25)26)14-3-1-2-12-11(14)5-7-28-17(12)32/h1-9H,(H,28,32)(H,27,30,33) | [InChIKey]
APWRZPQBPCAXFP-UHFFFAOYSA-N | [SMILES]
N1(C2=CC=CC3=C2C=CNC3=O)C(C(F)(F)F)=C(C(NC2C=CN=C(C(F)(F)F)C=2)=O)C=N1 |
| Hazard Information | Back Directory | [Uses]
Safimaltib (JNJ-67856633) is an orally active, first-in-class, potent, selective and allosteric MALT1 protease inhibitor. Safimaltib in some cases lead to tumor stasis[1][2][3]. | [in vivo]
Dose dependent inhibition of the generation of Tregs (CD4+CD25+FoxP3+) following CD3/28 stimulation was observed upon treatment with JNJ-67856633 suggesting a potential immune modulatory role of MALT1 inhibition[3]. | [References]
[1] Virtual meeting delivers first time drug structures
[2] A Phase 1, First-in-Human, Open-Label Study of the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-67856633, an Inhibitor of MALT1, in Participants with NHL and CLL
[3] Abstract 5690: Discovery of JNJ-67856633: A novel, first-in-class MALT1 protease inhibitor for the treatment of B cell lymphomas |
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| Company Name: |
ChemShuttle, Inc.
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| Tel: |
0510-83588313-811 18800520310 |
| Website: |
www.jiehuapharma.com/ |
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