| Identification | Back Directory | [Name]
16,24-Cycloergostan-26-oic acid, 1,11,12-tris(acetyloxy)-2,3:22,23-diepoxy-7,15,23,25-tetrahydroxy-6-oxo-, γ-lactone, (1α,2α,3α,5α,7β,11α,12α,15α,16β,22R,23R,25S)- | [CAS]
2230777-09-8 | [Synonyms]
16,24-Cycloergostan-26-oic acid, 1,11,12-tris(acetyloxy)-2,3:22,23-diepoxy-7,15,23,25-tetrahydroxy-6-oxo-, γ-lactone, (1α,2α,3α,5α,7β,11α,12α,15α,16β,22R,23R,25S)- | [Molecular Formula]
C34H44O14 | [MOL File]
2230777-09-8.mol | [Molecular Weight]
676.7 |
| Chemical Properties | Back Directory | [Boiling point ]
779.0±60.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [solubility ]
Chloroform: Sparingly soluble: 1-10 mg/ml
Methanol: Slightly soluble: 0.1-1 mg/ml | [form ]
Solid | [pka]
11.83±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Taccalonolide AJ is a semi-synthesis compound with cellular microtubule stabilizing activity. Taccalonolide AJ exhibits high potency antiproliferative activity against cancer cells, with an IC50 of 4.2 nM for HeLa cells[1]. | [References]
[1] Li J, et al. Potent taccalonolides, AF and AJ, inform significant structure-activity relationships and tubulin as the binding site of these microtubule stabilizers. J Am Chem Soc. 2011 Nov 30;133(47):19064-7. DOI:10.1021/ja209045k |
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