| Identification | Back Directory | [Name]
JT001 sodium | [CAS]
2238820-09-0 | [Synonyms]
JT001 sodium
5H-Pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-6,7-dihydro-, sodium salt (1:1) | [Molecular Formula]
C19H22N4O4S.Na | [MOL File]
2238820-09-0.mol | [Molecular Weight]
425.46 |
| Hazard Information | Back Directory | [Uses]
JT001 (NLRP3-IN-19) sodium is a potent, specific and orally active inhibitor of NLRP3. JT001 sodium can inhibit NLRP3 inflammasome assembly, resulting in the inhibition of cytokine release and the prevention of pyroptosis. JT001 sodium can be used for the research of nonalcoholic steatohepatitis and liver fibrosis[1]. | [IC 50]
NLRP3 | [References]
[1] Povero D, et, al. Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis. J Pharmacol Exp Ther. 2023 Aug;386(2):242-258. DOI:10.1124/jpet.123.001639 |
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