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2238844-74-9

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2238844-74-9 Structure

2238844-74-9 Structure
IdentificationBack Directory
[Name]

BocNH-PEG10-OH
[CAS]

2238844-74-9
[Synonyms]

BocNH-PEG10-OH
[Molecular Formula]

C25H51NO12
[MOL File]

2238844-74-9.mol
[Molecular Weight]

557.67
Chemical PropertiesBack Directory
[Boiling point ]

615.2±55.0 °C(Predicted)
[density ]

1.097±0.06 g/cm3(Predicted)
[pka]

12.23±0.46(Predicted)
Hazard InformationBack Directory
[Uses]

N-Boc-PEG10-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[Biological Activity]

N-Boc-PEG10-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[IC 50]

PEGs
[References]

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
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