| Identification | Back Directory | [Name]
MF-094 | [CAS]
2241025-68-1 | [Synonyms]
MF-094
MF094,Deubiquitinase,MF-094,MF 094,inhibit,DUBs,Inhibitor
Benzenepropanamide, α-[(cyclohexylcarbonyl)amino]-N-[5-[[(1,1-dimethylethyl)amino]sulfonyl]-1-naphthalenyl]-, (αS)- | [Molecular Formula]
C30H37N3O4S | [MDL Number]
MFCD31813673 | [MOL File]
2241025-68-1.mol | [Molecular Weight]
535.7 |
| Chemical Properties | Back Directory | [density ]
1.229±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (233.34 mM) | [form ]
Solid | [pka]
11.96±0.50(Predicted) | [color ]
Light yellow to yellow | [InChIKey]
DQXORJHBZHLLTE-SANMLTNESA-N | [SMILES]
[S](=O)(=O)(NC(C)(C)C)c1c2c(c(ccc2)NC(=O)[C@@H](NC(=O)C4CCCCC4)Cc3ccccc3)ccc1 |
| Hazard Information | Back Directory | [Uses]
MF-094 is a potent and selective USP30 inhibitor with an IC50 of 120 nM. MF-094 increases protein ubiquitination and accelerates mitophagy[1]. | [Biological Activity]
MF-094 is a potent inhibitor of ubiquitin specific protease 30 (USP30)a de-ubiquitinating enzymes (DUB) th at opposes the action of parkin-mediated ubiquitination in clearing damaged mitochondria. MF-094 is selective for USP30 with an IC50 value of 120 nMcompared to >10 μM for USPs 18and 9. | [References]
[1] Kluge AF, et al. Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy. Bioorg Med Chem Lett. 2018 Aug 15;28(15):2655-2659. DOI:10.1016/j.bmcl.2018.05.013 |
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