| Identification | Back Directory | [Name]
Benzamide, 4-[[3-amino-6-(3,5-dimethyl-4-isoxazolyl)-2-pyrazinyl]oxy]-N-(3-chlorophenyl)- | [CAS]
2241914-86-1 | [Synonyms]
Aurora Kinases-IN-2
Benzamide, 4-[[3-amino-6-(3,5-dimethyl-4-isoxazolyl)-2-pyrazinyl]oxy]-N-(3-chlorophenyl)- | [Molecular Formula]
C22H18ClN5O3 | [MOL File]
2241914-86-1.mol | [Molecular Weight]
435.86 |
| Hazard Information | Back Directory | [Uses]
Aurora kinase-IN-2 (compound 12Aj) is a potent Aurora kinase inhibitor with IC50 values of 90 and 152 nM for Aurora A and Aurora B. Aurora kinase-IN-2 arrests cell cycle at G2/M phase by regulating cyclin B1 and cdc2. Aurora kinase-IN-2 can be used for cancer research[1]. | [IC 50]
Aurora A: 90 nM (IC50); Aurora B: 152 nM (IC50) | [References]
[1] Bo YX, et, al. Synthesis, biological evaluation and molecular modeling study of 2-amino-3,5-disubstituted-pyrazines as Aurora kinases inhibitors. Bioorg Med Chem. 2020 Mar 1;28(5):115351. DOI:10.1016/j.bmc.2020.115351 |
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