ChemicalBook--->CAS DataBase List--->2243942-52-9

2243942-52-9

2243942-52-9 Structure

2243942-52-9 Structure
IdentificationBack Directory
[Name]

HO-PEG24-OH
[CAS]

2243942-52-9
[Synonyms]

HO-PEG24-OH
OH-PEG24-OH
3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60,63,66,69-Tricosaoxahenheptacontane-1,71-diol
[Molecular Formula]

C48H98O25
[MDL Number]

MFCD28976705
[MOL File]

2243942-52-9.mol
[Molecular Weight]

1075.28
Chemical PropertiesBack Directory
[Boiling point ]

906.6±60.0 °C(Predicted)
[density ]

1.117±0.06 g/cm3(Predicted)
[storage temp. ]

Storage temp. 2-8°C
[solubility ]

DMSO : 50 mg/mL (46.50 mM; Need ultrasonic)
[form ]

Solid
[pka]

14.06±0.10(Predicted)
[color ]

White to off-white
[InChIKey]

IEXKUCOGQITOPO-UHFFFAOYSA-N
[SMILES]

C(O)COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319
[Precautionary statements ]

P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330
Hazard InformationBack Directory
[Description]

PEG25 contains repeating ethylene glycol subunits with two terminal hydroxyl groups. The hydroxyl groups can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound under aqueous environments. The water solubility properties of the PEG linker are enhanced with longer PEG chains.
[Uses]

HO-PEG24-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Spectrum DetailBack Directory
[Spectrum Detail]

HO-PEG24-OH(2243942-52-9)1HNMR
HO-PEG24-OH(2243942-52-9)13CNMR
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