| Identification | Back Directory | [Name]
Thalidomide-NH-C4-NH2 TFA | [CAS]
2093387-50-7 | [Synonyms]
halidomide-NH-C4-NH2TFA
Pomalidomide-C4-NH2 TFA
Thalidomide-NH-C4-NH2 TFA
Pomalidomide Related Compound 10 Triflate
4-((4-aminobutyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 2,2,2-trifluoroacetate | [Molecular Formula]
C19H21F3N4O6 | [MDL Number]
MFCD32903491 | [MOL File]
2093387-50-7.mol | [Molecular Weight]
458.39 |
| Hazard Information | Back Directory | [Uses]
Thalidomide-NH-C4-NH2 TFA (compound 29c) is an E3 ligase ligand-linker conjugate, and incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-NH-C4-NH2 TFA is used in PROTAC BRD2/BRD4 degrader-1 (HY-130612). PROTAC BRD2/BRD4 degrader-1 is a potent and selective BET protein BRD4 and BRD2 degrader[1]. | [Biological Activity]
Thalidomide-NH-C4-NH2 TFA (compound 29c) is an E3 ligase ligand-linker conjugate, and incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-NH-C4-NH2 TFA is used in PROTAC BRD2/BRD4 degrader-1 . PROTAC BRD2/BRD4 degrader-1 is a potent and selective BET protein BRD4 and BRD2 degrader[1]. | [IC 50]
Cereblon | [References]
[1]. Jiang F, et al. Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies. Bioorg Med Chem. 2020 Jan 1;28(1):115181. |
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