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2245698-48-8

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2245698-48-8 Structure

2245698-48-8 Structure
IdentificationBack Directory
[Name]

DM4-SPDP
[CAS]

2245698-48-8
[Synonyms]

DM4-SPDP
Maytansine, N2'-deacetyl-N2'-[4-[[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl]dithio]-4-methyl-1-oxopentyl]-
[Molecular Formula]

C45H61ClN4O14S2
[MDL Number]

MFCD28400105
[MOL File]

2245698-48-8.mol
[Molecular Weight]

981.57
Chemical PropertiesBack Directory
[density ]

1.38±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[pka]

9.82±0.70(Predicted)
Hazard InformationBack Directory
[Uses]

(R)-DM4-SPDP is a conjugate made up of the linker SPDP and the toxic molecule DM4, and it can be used to prepare antibody-drug conjugates[1].
[storage]

Store at -20°C
[References]

[1] Silvana T Tivadar, et al. Monoclonal Antibody Targeting Sialyl-di-Lewisa-Containing Internalizing and Noninternalizing Glycoproteins with Cancer Immunotherapy Development Potential. Mol Cancer Ther. 2020 Mar;19(3):790-801. DOI:10.1158/1535-7163.MCT-19-0221
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