| Chemical Properties | Back Directory | [Boiling point ]
1577.6±65.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [solubility ]
DMSO : 250 mg/mL (149.52 mM; Need ultrasonic) | [form ]
Solid | [pka]
3.56±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
DBCO-PEG4-Val-Cit-PAB-MMAF consists a cleavable 4 unit PEG ADC linker (DBCO-PEG4-Val-Cit-PAB) and a potent tubulin polymerization inhibitor (MMAF). DBCO-PEG4-Val-Cit-PAB-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-PEG4-Val-Cit-PAB-MMAF is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
Auristatin | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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| Company Name: |
YantaiBio
|
| Tel: |
13758194781; 13758194781 |
| Website: |
|
| Company Name: |
TargetMol
|
| Tel: |
400-821-0310 15002144251 |
| Website: |
www.targetmol.cn/ |
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