| Identification | Back Directory | [Name]
TUG-1375 | [CAS]
2247372-59-2 | [Synonyms]
TUG-1375
TUG1375;TUG 1375
4-Thiazolidinecarboxylic acid, 2-(2-chlorophenyl)-3-[4-(3,5-dimethyl-4-isoxazolyl)benzoyl]-, (2R,4R)- | [Molecular Formula]
C22H19ClN2O4S | [MDL Number]
MFCD32062757 | [MOL File]
2247372-59-2.mol | [Molecular Weight]
442.92 |
| Chemical Properties | Back Directory | [Boiling point ]
660.8±55.0 °C(Predicted) | [density ]
1.390±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMSO : 125 mg/mL (282.22 mM) | [form ]
Solid | [pka]
3.12±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TUG-1375 is an agonist of free fatty acid receptor 2 (FFA2/GPR43), with a pKi of 6.69. TUG-1375 is inactive on FFA3, FFA4, PPARα, PPARγ, PPARδ, LXRα or LXRβ[1]. | [References]
[1] Hansen AH, et al. Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties. J Med Chem. 2018 Nov 8;61(21):9534-9550. DOI:10.1021/acs.jmedchem.8b00855 |
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