| Identification | Back Directory | [Name]
INDEX NAME NOT YET ASSIGNED | [CAS]
2248726-53-4 | [Synonyms]
SAR-441566
SAR-441566(TNFα activity modulator 3)
(7R,14R)-11-[2-(1-aminocyclobutyl)-5-pyrimidinyl]-1-(difluoromethoxy)-6,7-dihydro-6-methyl-7,14-Methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)-one
7,14-Methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)-one, 11-[2-(1-aminocyclobutyl)-5-pyrimidinyl]-1-(difluoromethoxy)-6,7-dihydro-6-methyl-, (7R,14R)- | [Molecular Formula]
C27H24F2N6O2 | [MOL File]
2248726-53-4.mol | [Molecular Weight]
502.52 |
| Chemical Properties | Back Directory | [Boiling point ]
735.4±60.0 °C(Predicted) | [density ]
1.60±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
8.70±0.20(Predicted) | [color ]
White to off-white | [InChIKey]
UROFXMLQPAUCGV-WOJBJXKFSA-N | [SMILES]
O(C1C=CC=C2C(N([C@]3([H])C[C@]([H])(C2=1)N1C2=CC(C4=CN=C(C5(CCC5)N)N=C4)=CC=C2N=C13)C)=O)C(F)F |
| Hazard Information | Back Directory | [Uses]
TNFα activity modulator 3 (example 6) is a modulator of TNF activity that inhibits TNFα-induced NF-κB activation and can be utilized in relevant research[1]. | [References]
[1] Daniel C, et al. Fused pentacyclic imidazole derivatives as modulators of tnf activity, WO2018197503A1, 2018-11-01 |
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