| Identification | Back Directory | [Name]
CRT0066854 hydrochloride | [CAS]
2250019-91-9 | [Synonyms]
CRT0066854 hydrochloride
CRT-0066854 hydrochloride,CRT0066854 hydrochloride | [Molecular Formula]
C24H26ClN5S | [MDL Number]
MFCD34470294 | [MOL File]
2250019-91-9.mol | [Molecular Weight]
452.02 |
| Hazard Information | Back Directory | [Description]
Protein kinase C (PKC) inhibitor. Inhibits PKCΙ and PKCζ; (IC50 values are 132 and 639 nM, respectively). Restores polarized morphogenesis in oncogene expressing MDCK cells, decreases colony formation in HeLa cells and inhibits lethal giant larvae 2 (LLGL2) phosphorylation. | [Uses]
CRT0066854 hydrochloride is a potent and selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively[1]. | [IC 50]
PKCζ: 639 nM (IC50); ROCKII: 620 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Kj?r S, et al. Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes. Biochem J.?2013 Apr 15;451(2):329-42. DOI:10.1042/BJ20121871 |
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