| Identification | Back Directory | [Name]
JWG-071 | [CAS]
2250323-50-1 | [Synonyms]
JWG-071
6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-2-[[2-methoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5-methyl-11-(1-methylpropyl)- | [Molecular Formula]
C34H44N8O3 | [MOL File]
2250323-50-1.mol | [Molecular Weight]
612.77 |
| Chemical Properties | Back Directory | [Boiling point ]
801.7±75.0 °C(Predicted) | [density ]
1.238±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
8.14±0.42(Predicted) | [color ]
Light yellow to yellow | [InChIKey]
ACWOMSOYIIVIRV-UHFFFAOYSA-N | [SMILES]
N1(C(C)CC)C2=CC=CC=C2C(=O)N(C)C2=CN=C(NC3=CC=C(C(N4CCC(N5CCN(C)CC5)CC4)=O)C=C3OC)N=C12 |
| Hazard Information | Back Directory | [Uses]
JWG-071 is the kinase-selective chemical probe for ERK5. JWG-071 inhibits ERK5 and LRRK2 with IC50 values of 88nM and 109 nM, respectively[1]. | [Biological Activity]
JWG-071 is the first reported ERK5 kinase-selective chemical probe which can increases ERK5 activity and BRD4 selectivity. It will be a much-needed chemical probe for deconvoluted ERK5 and BRD4 pharmacology. | [in vitro]
JWG-071 inhibits ERK5 and LRRK2 with IC 50 of 88 and 109 nM, respectively. < /div> | [target]
| [IC 50]
ERK5: 88 nM (IC50) | [References]
[1] Wang J, et al. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinonesas Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448 DOI:10.1021/acschembio.7b00638 |
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| Company Name: |
DC Chemicals Gold
|
| Tel: |
021-58447131 13564518121 |
| Website: |
www.chemicalbook.com/showsupplierproductslist927327/0_en.htm |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
|