| Identification | More | [Name]
4-Bromo-2-hydroxybenzaldehyde | [CAS]
22532-62-3 | [Synonyms]
4-BROMO-2-HYDROXY-BENZALDEHYDE
4-Bromosalicylaldehyde
2-Hydroxy-4-Bromobenzaldehyde | [EINECS(EC#)]
636-586-5 | [Molecular Formula]
C7H5BrO2 | [MDL Number]
MFCD06252606 | [Molecular Weight]
201.02 | [MOL File]
22532-62-3.mol |
| Questions And Answer | Back Directory | [Synthesis]
Add 0.4 mol of m-bromophenol to a four-necked flask, then add 160 mL of 40% sodium hydroxide solution, connect the apparatus, stir thoroughly for 30 min, and cool to 65–70 °C. Add 0.0016 mol of tetrabutylammonium chloride, and add 52 mL of the mixture according to V(1,4-dioxane):V(isobutanol) = 30:1. Add 0.52 mol of chloroform to a dropping funnel. When the temperature rises to 50–60 °C, add the chloroform to the flask, controlling the rate to keep the temperature <70 °C. After all the chloroform has been added, stir the mixture and react for another 1 h, controlling the reaction temperature at 65–70 °C. After the reaction is complete, cool to room temperature. Add a 1:1 (v/v) hydrochloric acid solution to adjust the pH to 2-3. Filter the reaction mixture under reduced pressure to separate the solid and liquid phases. Transfer the liquid phase to a separatory funnel to separate the reddish-brown oil layer and the clear, transparent aqueous phase. Extract the aqueous layer three times with 20 mL of diethyl ether, combine the extracts with the oil layer, and evaporate the ether. Perform steam distillation. Add a saturated sodium bisulfite solution to the distillate and shake vigorously to precipitate the adduct. Decompose this adduct with 10% sulfuric acid and dry it in an anhydrous calcium chloride desiccator to obtain the 4-bromo-2-hydroxybenzaldehyde product.
 Figure 4-bromo-2-hydroxybenzaldehyde |
| Chemical Properties | Back Directory | [Melting point ]
50-54 °C | [Boiling point ]
48-52 °C(Press: 0.04 Torr) | [density ]
1.737±0.06 g/cm3(Predicted) | [Fp ]
110 °C | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
Soluble in methanol. | [form ]
powder to crystal | [pka]
7.21±0.10(Predicted) | [color ]
White to Light yellow to Light orange | [InChI]
InChI=1S/C7H5BrO2/c8-6-2-1-5(4-9)7(10)3-6/h1-4,10H | [InChIKey]
HXTWKHXDFATMSP-UHFFFAOYSA-N | [SMILES]
C(=O)C1=CC=C(Br)C=C1O | [CAS DataBase Reference]
22532-62-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS07,GHS09 | [Signal word ]
Warning | [Hazard statements ]
H302-H410 | [Precautionary statements ]
P264-P270-P273-P301+P312-P391-P501 | [Hazard Codes ]
Xi,N,Xn | [Risk Statements ]
R22:Harmful if swallowed.
R50:Very Toxic to aquatic organisms. | [Safety Statements ]
S60:This material and/or its container must be disposed of as hazardous waste . | [RIDADR ]
UN 3077 9/PG 3 | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HazardClass ]
9 | [HazardClass ]
IRRITANT | [HS Code ]
2913000090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-white powder | [Uses]
4-Bromosalicylaldehyde is a substituted salicylaldehyde used in the synthesis of BIIB042, a γ-secretase modulator. | [Synthesis Reference(s)]
Journal of Medicinal Chemistry, 35, p. 734, 1992 DOI: 10.1021/jm00082a014 | [Hazard]
4-Bromo-2-hydroxybenzaldehyde is harmful if swallowed and very toxic to aquatic life, it causes serious eye irritation.
| [storage]
4-Bromo-2-hydroxybenzaldehyde can store long-term in a cool, dry place.
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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