| Identification | Back Directory | [Name]
5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine | [CAS]
2253745-70-7 | [Synonyms]
5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine | [Molecular Formula]
C27H27N3O | [MOL File]
2253745-70-7.mol | [Molecular Weight]
409.52 |
| Chemical Properties | Back Directory | [Boiling point ]
643.3±65.0 °C(Predicted) | [density ]
1.139±0.06 g/cm3(Predicted) | [solubility ]
Chloroform: 10 mg/ml; Ethanol: 10 mg/ml; Methyl Acetate: 1 mg/ml | [pka]
3.66±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1; IC50s = 117 and 60 nM for the human and mouse enzymes, respectively).1 It inhibits LPS-induced prostaglandin E2 (PGE2; ) production in mouse peritoneal cells (IC50 = 31 nM). In vivo, 5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine (25 mg/kg) reduces carrageenan-induced paw edema in rats. | [Uses]
mPGES1-IN-5 (compound 18) is a polysubstituted pyrimidine compound and a submicromolar PGE2 production inhibitor. It exerts its anti-inflammatory effect mainly by inhibiting mPGES-1 and has a significant inhibitory effect on the acute inflammation model in vivo. | [References]
1. Kal?ic, F., Kolman, V., Ajani, H., et al. Polysubstituted pyrimidines as mPGES-1 inhibitors: Discovery of potent inhibitors of PGE2 production with strong anti-inflammatory effects in carrageenan-induced rat paw edema ChemMedChem 15(15),1398-1407(2020). |
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| Company Name: |
ChemeGen
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| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
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