ChemicalBook--->CAS DataBase List--->2254409-25-9

2254409-25-9

2254409-25-9 Structure

2254409-25-9 Structure
IdentificationBack Directory
[Name]

ALK2-IN-2
[CAS]

2254409-25-9
[Synonyms]

ALK2-IN-2
ALK2 inhibitor 2
[Molecular Formula]

C28H27N5O2S
[MDL Number]

MFCD32067886
[MOL File]

2254409-25-9.mol
[Molecular Weight]

497.61
Chemical PropertiesBack Directory
[density ]

1.38±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 125 mg/mL (251.20 mM; Need ultrasonic)
[form ]

Solid
[pka]

9.82±0.30(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) with an IC50 of 9 nM, and over 700-fold selectivity against ALK3[1].
[IC 50]

ACVR1: 9 nM (IC50)
[References]

[1] Jiang JK, et al. Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3356-3362. DOI:10.1016/j.bmcl.2018.09.006
Spectrum DetailBack Directory
[Spectrum Detail]

ALK2-IN-2(2254409-25-9)1HNMR
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2254409-25-9