| Identification | Back Directory | [Name]
1H-Pyrrolo[3,2-b]pyridine-1-carboxylic acid, 6-[2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl]-2,3-dihydro-, tetrahydro-2H-pyran-4-yl ester | [CAS]
2258671-41-7 | [Synonyms]
1H-Pyrrolo[3,2-b]pyridine-1-carboxylic acid, 6-[2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl]-2,3-dihydro-, tetrahydro-2H-pyran-4-yl ester | [Molecular Formula]
C24H25N5O4 | [MOL File]
2258671-41-7.mol | [Molecular Weight]
447.49 |
| Hazard Information | Back Directory | [Uses]
Zharp1-211 is a potent inhibitor of RIPK1 kinase. Zharp1-211 significantly reduces the expression of JAK/STAT1-mediated chemokines and MHC class II molecules in intestinal epithelial cells[1]. | [References]
[1] Yu X, et al. A novel RIPK1 inhibitor reduces GVHD in mice via a nonimmunosuppressive mechanism that restores intestinal homeostasis. Blood. 2023 Mar 2;141(9):1070-1086. DOI:10.1182/blood.2022017262 |
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