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2259318-56-2

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2259318-56-2 Structure

2259318-56-2 Structure
IdentificationBack Directory
[Name]

DBCO-PEG4-VC-PAB-DMEA-PNU-159682
[CAS]

2259318-56-2
[Synonyms]

DBCO-PEG4-VC-PAB-DMEA-PNU-159682
[Molecular Formula]

C86H106N10O26
[MDL Number]

MFCD34469597
[MOL File]

2259318-56-2.mol
[Molecular Weight]

1695.81
Chemical PropertiesBack Directory
[density ]

1.43±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

7.33±0.60(Predicted)
[color ]

Orange to red
Hazard InformationBack Directory
[Uses]

DBCO-PEG4-VC-PAB-DMEA-PNU-159682, a agent-linker conjugate for ADC, consists the ADC linker DBCO-PEG4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 includes metabolites of nemorubicin (MMDX) from liver microsomes and ADC cytotoxin PNU-159682. DBCO-PEG4-VC-PAB-DMEA-PNU-159682 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
[IC 50]

Duocarmycins
[References]

[1] John Flygare, et al. Anthracycline disulfide intermediates, antibody-drug conjugates and methods. WO2016040825A1
2259318-56-2 suppliers list
Company Name: TargetMol Chemicals Inc.  
Telephone: 15002134094
Website: https://www.targetmol.cn/
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