| Identification | Back Directory | [Name]
DBCO-PEG4-VC-PAB-DMEA-PNU-159682 | [CAS]
2259318-56-2 | [Synonyms]
DBCO-PEG4-VC-PAB-DMEA-PNU-159682 | [Molecular Formula]
C86H106N10O26 | [MDL Number]
MFCD34469597 | [MOL File]
2259318-56-2.mol | [Molecular Weight]
1695.81 |
| Hazard Information | Back Directory | [Uses]
DBCO-PEG4-VC-PAB-DMEA-PNU-159682, a agent-linker conjugate for ADC, consists the ADC linker DBCO-PEG4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 includes metabolites of nemorubicin (MMDX) from liver microsomes and ADC cytotoxin PNU-159682. DBCO-PEG4-VC-PAB-DMEA-PNU-159682 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
Duocarmycins | [References]
[1] John Flygare, et al. Anthracycline disulfide intermediates, antibody-drug conjugates and methods. WO2016040825A1 |
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