| Identification | Back Directory | [Name]
Propargyl-PEG12-N3 | [CAS]
2264091-72-5 | [Synonyms]
Propargyl-PEG12-N3
Azido-PEG12-propargyl
3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxanonatriacont-38-yne, 1-azido- | [Molecular Formula]
C27H51N3O12 | [MDL Number]
MFCD34473264 | [MOL File]
2264091-72-5.mol | [Molecular Weight]
609.71 |
| Hazard Information | Back Directory | [Uses]
Azido-PEG12-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG12-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1014. DOI:10.1016/j.chembiol.2020.07.020 |
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