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2264091-73-6

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2264091-73-6 Structure

2264091-73-6 Structure
IdentificationBack Directory
[Name]

Propargyl-PEG12-amine
[CAS]

2264091-73-6
[Synonyms]

Propyne-PEG12-NH2
Propargyl-PEG12-amine
Propargyl-PEG13- Amine
[Molecular Formula]

C27H53NO12
[MOL File]

2264091-73-6.mol
[Molecular Weight]

583.71
Chemical PropertiesBack Directory
[Boiling point ]

608.1±50.0 °C(Predicted)
[density ]

1.084±0.06 g/cm3(Predicted)
[pka]

8.74±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

Propargyl-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG12-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
[Biological Activity]

Propargyl-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[IC 50]

PEGs
[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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