| Identification | Back Directory | [Name]
Propargyl-PEG12-amine | [CAS]
2264091-73-6 | [Synonyms]
Propyne-PEG12-NH2
Propargyl-PEG12-amine
Propargyl-PEG13- Amine | [Molecular Formula]
C27H53NO12 | [MOL File]
2264091-73-6.mol | [Molecular Weight]
583.71 |
| Hazard Information | Back Directory | [Uses]
Propargyl-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG12-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [Biological Activity]
Propargyl-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
PEGs | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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Xinyanpomei
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15850660754 |
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http://www.xinyanpomei.com |
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