| Identification | Back Directory | [Name]
H2N-PEG4-Propyne | [CAS]
1013921-36-2 | [Synonyms]
1013921-36-2
Alkyne-PEG4-NH2
H2N-PEG4-Propyne
Alkyne-PEG4-Amine
HC≡C-CH2-PEG4-NH2
Amino-PEG4-alkyne
Propyne-PEG4-amine
PROPARGYL-PEG4-NH2
Acetylene-PEG4-amine
Propargyl-PEG4-amine
1-Amino-3,6,9,12-tetraoxapentadec-14-yne
Triethylene glycol 2-aminoethyl propargyl ether
Propargyl-PEG4-amine, Alkyne-PEG4-Amine,Amino-PEG4-alkyne | [Molecular Formula]
C11H21NO4 | [MDL Number]
MFCD22380736 | [MOL File]
1013921-36-2.mol | [Molecular Weight]
231.29 |
| Chemical Properties | Back Directory | [Boiling point ]
315.9±32.0 °C(Predicted) | [density ]
1.037±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO, DMF, DCM, THF, or chloroform. | [form ]
Solid | [pka]
8.74±0.10(Predicted) | [color ]
Pale Yellow | [Appearance]
Colorless or light yellow oil | [InChI]
1S/C11H21NO4/c1-2-4-13-6-8-15-10-11-16-9-7-14-5-3-12/h1H,3-12H2 | [InChIKey]
QDLPAHLHHBCWOW-UHFFFAOYSA-N | [SMILES]
NCCOCCOCCOCCOCC#C |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG4-amine has a propargyl group and an amine group. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls, etc. The propargyl group can form triazole linkage with azide-bearing biomolecules. | [Uses]
1-Amino-3,6,9,12-tetraoxapentadec-14-yne is used as a acetylene containing reagent with PEG spacer and carboxyl reactivity. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification of carboxylic acid containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character. | [reaction suitability]
reaction type: click chemistry
reagent type: cross-linking reagent | [IC 50]
PEGs |
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