| Chemical Properties | Back Directory | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 25 mg/mL (52.19 mM; Need ultrasonic) | [form ]
Solid | [pka]
7.87±0.50(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
UMB298 is a potent and selective CBP/P300 bromodomain inhibitor[1]. | [Biological Activity]
UMB298 is a potent and selective CBP/P300 bromodomain inhibitor[1].
UMB298 (0.01~10 μM; 50 days; MOLM13 and MM cells) inhibits cells growth[1].UMB298 (1~10 μM; 2 hours; MOLM13 cells) reduces the H3K27ac level similar to CBP30 and causes MYC depletion as a signature of CBP inhibition in acute myeloid leukemia[1].UMB298 (3 μM; 2hours; MOLM13 cells) down-regulates MYC expression[1]. | [IC 50]
BRD4: 5193 nM (IC50) | [storage]
Store at -20°C | [References]
[1]. Muthengi A, et al. Development of Dimethylisoxazole-Attached Imidazo[1,2-a]pyridines as Potent and Selective CBP/P300 Inhibitors. J Med Chem. 2021;64(9):5787-5801. |
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