| Identification | Back Directory | [Name]
4-Quinazolinamine, N-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-N-methyl-2-(3-pyridinyl)- | [CAS]
2270984-21-7 | [Synonyms]
Gcase activator 3
4-Quinazolinamine, N-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-N-methyl-2-(3-pyridinyl)- | [Molecular Formula]
C23H20N4O2 | [MOL File]
2270984-21-7.mol | [Molecular Weight]
384.43 |
| Hazard Information | Back Directory | [Uses]
Gcase activator 3 (compound 9Q) is a glucosidase (Glucosidase, GCase) activator that can partially stabilize GCase and increase its activity. Gcase activator 3 reduces mutant GCase protein misfolding and degradation in fibroblasts and dopaminergic midbrain neurons. Gcase activator 3 can be used in the study of Parkinson's disease (PD) and related synucleinopathies[1]. | [References]
[1] Zheng J, et al. Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. J Med Chem. 2019 Feb 14;62(3):1218-1230. DOI:10.1021/acs.jmedchem.8b01294 |
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