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2278278-04-7

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2278278-04-7 Structure

2278278-04-7 Structure

Identification	Back Directory
[Name] Urea, N-[5-(1,1-dimethylethyl)-3-isoxazolyl]-N'-[2-[(5-hydroxy-1H-indol-2-yl)carbonyl]-5-benzofuranyl]-
[CAS] 2278278-04-7
[Synonyms] FLT3/ITD-IN-4 Urea, N-[5-(1,1-dimethylethyl)-3-isoxazolyl]-N'-[2-[(5-hydroxy-1H-indol-2-yl)carbonyl]-5-benzofuranyl]-
[Molecular Formula] C25H22N4O5
[MOL File] 2278278-04-7.mol
[Molecular Weight] 458.47

Chemical Properties	Back Directory
[Boiling point ] 636.7±55.0 °C(Predicted)
[density ] 1.439±0.06 g/cm3(Predicted)
[pka] 9.54±0.40(Predicted)

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[Uses] FLT3/ITD-IN-4 (Compound 16) is a selective FMS-like tyrosine kinase 3 internal tandem duplications (FLT3-ITD) inhibitor with an IC50 of 2.3 nM. FLT3/ITD-IN-4 can be used for acute myeloid leukemia research[1].
[IC 50] FLT3-ITD: 2.3 nM (IC₅₀); FLT3 D835Y: 4.84 nM (IC₅₀); RET: 277 nM (EC₅₀); FLT3: 443 nM (EC₅₀); ZAK/MLTK: 1069 nM (EC₅₀); CDK16/Cyclin Y: 1768 nM (EC₅₀); DDR2: 2494 nM (EC₅₀); EPHA7: 3255 nM (EC₅₀); NTRK1: 3857 nM (EC₅₀); MAP4K4: 5737 nM (EC₅₀)
[References] [1] Sellmer A, et al. A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia. Eur J Med Chem. 2020 May 1;193:112232. DOI:10.1016/j.ejmech.2020.112232

2278278-04-7 suppliers list

Company Name:	Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd
Telephone:	15317229551
Website:	https://www.ureiko.com

Company Name:	TargetMol Chemicals Inc.
Telephone:	15002134094
Website:	https://www.targetmol.cn/

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2278278-04-7 1604810-83-4 53-85-0 186692-46-6