| Identification | Back Directory | [Name]
1H-Indene-5,6-diol, 1-nonylidene-3-(trifluoromethyl)- | [CAS]
2285446-67-3 | [Synonyms]
(E/Z)-E64FC26
1H-Indene-5,6-diol, 1-nonylidene-3-(trifluoromethyl)- | [Molecular Formula]
C19H23F3O2 | [MOL File]
2285446-67-3.mol | [Molecular Weight]
340.38 |
| Chemical Properties | Back Directory | [Boiling point ]
423.0±45.0 °C(Predicted) | [density ]
1.249±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
8.73±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
(E/Z)-E64FC26 is a mixture complex of E-E64FC26 and Z-E64FC26. E64FC26 (E-E64FC26) is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. E64FC26 shows anti-myeloma activity[1][2]. | [References]
[1] Nathan G. Dolloff, et al. Indene derivatives and uses thereof. US20190062298A1.
[2] Robinson RM, et al. Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma. Leukemia. 2019 Apr;33(4):1011-1022. DOI:10.1038/s41375-018-0263-1 |
|
|