| Identification | Back Directory | [Name]
JAK3 covalent inhibitor-1 | [CAS]
2300106-50-5 | [Synonyms]
JAK3 COVALENT INHIBITOR-1
JAK3 covalent inhibitor1,JAK3 covalent inhibitor 1,JAK-3 covalent inhibitor-1 | [Molecular Formula]
C22H17FN6O2S | [MDL Number]
MFCD32067927 | [MOL File]
2300106-50-5.mol | [Molecular Weight]
448.47 |
| Hazard Information | Back Directory | [Description]
JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs[1].
JAK3|11 nM (IC50)
| [Uses]
JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs[1]. | [IC 50]
JAK3: 11 nM (IC50) | [storage]
Store at -20°C | [References]
[1]. Casimiro-Garcia A, et al. Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors. J Med Chem. 2018 Dec 13;61(23):10665-10699. |
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