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2304503-05-5

2304503-05-5 Structure

2304503-05-5 Structure
IdentificationBack Directory
[Name]

NQO1 substrate
[CAS]

2304503-05-5
[Synonyms]

NQO1 substrate
[Molecular Formula]

C13H2F2N4O
[MDL Number]

MFCD32067905
[MOL File]

2304503-05-5.mol
[Molecular Weight]

268.18
Chemical PropertiesBack Directory
[Boiling point ]

593.0±50.0 °C(Predicted)
[density ]

1.69±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 125 mg/mL (466.10 mM)
[form ]

Solid
[pka]

-10.35±0.20(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

NQO1 substrate acts as an efficient NQO1 substrate and may be a new option for the treatment of NQO1-overexpresssing drug-resistant NSCLC[1].
[storage]

Store at -20°C
[References]

[1] Wu X, et al. Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer. J Med Chem. 2018 Dec 27;61(24):11280-11297. DOI:10.1021/acs.jmedchem.8b01424
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