| Identification | Back Directory | [Name]
3-Pyrrolidinecarboxamide, 1-(7-chloro-1H-indazol-3-yl)-N-[2-(1H-imidazol-5-yl)ethyl]-5-oxo- | [CAS]
2305204-24-2 | [Synonyms]
3-Pyrrolidinecarboxamide, 1-(7-chloro-1H-indazol-3-yl)-N-[2-(1H-imidazol-5-yl)ethyl]-5-oxo- | [Molecular Formula]
C17H17ClN6O2 | [MOL File]
2305204-24-2.mol | [Molecular Weight]
372.81 |
| Chemical Properties | Back Directory | [Boiling point ]
895.2±65.0 °C(Predicted) | [density ]
1.510±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
11.26±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PAC1R antagonist 1 (compound 3d) is a potent and orally active antagonist of PAC1 receptor. PAC1R antagonist 1 can inhibit pituitary adenylate cyclase-activating polypeptide (PACAP)- and nerve injury-induced allodynia[1]. | [References]
[1] Takasaki I, et, al. Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain. Eur J Med Chem. 2020 Jan 15;186:111902. DOI:10.1016/j.ejmech.2019.111902 |
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