| Identification | Back Directory | [Name]
Sphynolactone-7 | [CAS]
2305752-57-0 | [Synonyms]
SPL 7
Sphynolactone-7
4-Methyl-5-oxo-2,5-dihydrofuran-2-yl 4-[(4-Butoxyphenyl)sulfonyl]piperazine-1-carboxylate
1-Piperazinecarboxylic acid, 4-[(4-butoxyphenyl)sulfonyl]-, 2,5-dihydro-4-methyl-5-oxo-2-furanyl ester | [Molecular Formula]
C20H26N2O7S | [MDL Number]
MFCD32641453 | [MOL File]
2305752-57-0.mol | [Molecular Weight]
438.49 |
| Chemical Properties | Back Directory | [Boiling point ]
632.5±65.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: warmed, soluble | [form ]
A solid | [pka]
-2.48±0.70(Predicted) | [color ]
white to beige | [InChIKey]
GGAPQPVAXJSNFU-UHFFFAOYSA-N | [SMILES]
CCCCOC1=CC=C(S(N2CCN(C(OC3C=C(C)C(O3)=O)=O)CC2)(=O)=O)C=C1 |
| Hazard Information | Back Directory | [Uses]
Sphynolactone-7 (SPL7) is an active site-targeting and selective strigolactone receptor (ShHTL7) agonist. Sphynolactone-7 is effective for reducing Striga parasitism without impinging on host strigolactone-related processes[1]. | [Biological Activity]
Sphynolactone-7 (SPL-7) is an active site-targetinghighly potent and selective strigolactone receptor ShHTL7 agonist (YLG competitive binding IC50 = 310 nM/ShHTL71.2 μM/ShHTL8>7.0 μM/ShHTL2-6ShHTL9-11AtD14) th at acts as a seeds germination stimulant with femtomolar- and picomolar-level potencyrespectivelytoward the parasitic plants Striga hermonthica ecotypes and Orobanche minorwhile exhibiting no Arabidopsis-stimulatory efficacy. | [References]
[1] Uraguchi D, et al. A femtomolar-range suicide germination stimulant for the parasitic plant Striga hermonthica. Science. 2018 Dec 14;362(6420):1301-1305. DOI:10.1126/science.aau5445 |
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