| Identification | Back Directory | [Name]
E3 ligase Ligand-Linker Conjugates 55 | [CAS]
2328070-52-4 | [Synonyms]
Pomalidomide-amido-PEG3-C2-NH2
Cereblon Ligand-Linker Conjugates 22
E3 ligase Ligand-Linker Conjugates 55
Propanamide, 3-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]- | [Molecular Formula]
C22H28N4O8 | [MDL Number]
MFCD33029235 | [MOL File]
2328070-52-4.mol | [Molecular Weight]
476.48 |
| Chemical Properties | Back Directory | [Boiling point ]
764.7±60.0 °C(Predicted) | [density ]
1.388±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
10.69±0.40(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Pomalidomide-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology[1]. | [IC 50]
Cereblon | [References]
[1] Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520. DOI:10.1021/acs.jmedchem.8b01826 |
|
|