| Identification | Back Directory | [Name]
1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) | [CAS]
2305369-00-8 | [Synonyms]
Thalidomide-NH-C2-NH2.HCl
Pomalidomide-C2-NH2 hydrochloride
E3 ligase Ligand 17 hydrochloride
Cereblon Ligand-Linker Conjugates 15 (hydrochloride)
4-(2-aminoethylamino)-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
4-((2-aminoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
4-[(2-aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl
)-2,3-dihydro-1H-isoindole-1,3-dione
hydrochloride
1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) | [Molecular Formula]
C15H17ClN4O4 | [MOL File]
2305369-00-8.mol | [Molecular Weight]
352.78 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [form ]
Solid | [color ]
Light yellow to yellow | [InChI]
InChI=1S/C15H16N4O4.ClH/c16-6-7-17-9-3-1-2-8-12(9)15(23)19(14(8)22)10-4-5-11(20)18-13(10)21;/h1-3,10,17H,4-7,16H2,(H,18,20,21);1H | [InChIKey]
DSJCOXQYDMWPEY-UHFFFAOYSA-N | [SMILES]
O=C1N(C2CCC(=O)NC2=O)C(=O)C2=CC=CC(NCCN)=C12.Cl |
| Hazard Information | Back Directory | [Uses]
Pomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. | [Biological Activity]
Pomalidomide 4'-alkylC2-amine is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus an alkylC2 linker with terminal amine ready for conjugation to a target protein ligand. This product has been recently renamed. The previous name for this product was Pomalidomide - linker 7 | [IC 50]
Cereblon | [storage]
Store at -20°C | [References]
[1] Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575. DOI:10.1021/acs.jmedchem.7b00168 |
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