| Identification | Back Directory | [Name]
Pyrazolo[3,4-h]pyrrolo[3,2,1-no][6,1]benzoxaazacycloundecine-5-carboxylic acid, 1-chloro-15-ethyl-4-[3-[(6-fluoro-1-naphthalenyl)oxy]propyl]-7,8,9,10,12,14-hexahydro-14-methyl-12-[2-(4-morpholinyl)ethyl]-, (12R)- | [CAS]
2329719-65-3 | [Synonyms]
Pyrazolo[3,4-h]pyrrolo[3,2,1-no][6,1]benzoxaazacycloundecine-5-carboxylic acid, 1-chloro-15-ethyl-4-[3-[(6-fluoro-1-naphthalenyl)oxy]propyl]-7,8,9,10,12,14-hexahydro-14-methyl-12-[2-(4-morpholinyl)ethyl]-, (12R)- | [Molecular Formula]
C39H44ClFN4O5 | [MOL File]
2329719-65-3.mol | [Molecular Weight]
703.24 |
| Chemical Properties | Back Directory | [Boiling point ]
895.3±65.0 °C(predicted) | [density ]
1.35±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
4.45±0.40(predicted) |
| Hazard Information | Back Directory | [Uses]
BRD-810 is a highly selective MCL1 inhibitor. BRD-810 can bind to the BH3 groove of MCL1 and block the sequestration of pro-apoptotic proteins, quickly inducing caspase activation in MCL1-dependent cell lines. BRD-810 shows anti-tumor activity in models of blood cancers and solid tumors[1]. | [References]
[1] Rauh U, et al. BRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models. Nat Cancer. 2024 Aug 23. DOI:10.1038/s43018-024-00814-0 |
| Spectrum Detail | Back Directory | [Spectrum Detail]
Pyrazolo[3,4-h]pyrrolo[3,2,1-no][6,1]benzoxaazacycloundecine-5-carboxylic acid, 1-chloro-15-ethyl-4-[3-[(6-fluoro-1-naphthalenyl)oxy]propyl]-7,8,9,10,12,14-hexahydro-14-methyl-12-[2-(4-morpholinyl)ethyl]-, (12R)-(2329719-65-3)1HNMR
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TargetMol
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