| Identification | Back Directory | [Name]
9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]- | [CAS]
2342583-66-6 | [Synonyms]
9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]- | [Molecular Formula]
C22H28F3N7 | [MDL Number]
MFCD32067989 | [MOL File]
2342583-66-6.mol | [Molecular Weight]
447.5 |
| Chemical Properties | Back Directory | [Boiling point ]
573.5±60.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
9.02±0.28(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
NCC007 is a dual casein kinase Iα (CKIα) and δ (CKIδ) inhibitor with IC50s of 1.8 and 3.6 μM, respectively. NCC007 can be used in research of modulating mammalian circadian rhythms[1]. | [Biological Activity]
NCC007 is a dual casein kinase Iα (CKIα) and delta (CKIδ) inhibitor with IC50 of 1.8 and 3.6 μM, respectively. It can be used for the study of mammalian circadian rhythms. | [in vivo]
NCC007 (5-15 mM, infused into the lateral ventricle) controls circadian rhythms through CKI inhibition. | Animal Model: | Adult C57BL/6J background male mice (8 weeks old) | | Dosage: | 5 , 15 mM | | Administration: | Infused into the lateral ventricle, constant dark condition | | Result: | Showed more period lengthening effect with 0.15 hours at 5 mM and 15 mM. | < /tr> | [target]
| CKIα 1.8 μM (IC 50 ) | CKIδ 3.6 μM (IC 50 ) | | [IC 50]
CKIα: 1.8 μM (IC50); CKIδ: 3.6 μM (IC50) | [References]
[1] Lee JW, et al. Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ. J Med Chem. 2019 Feb 28;62(4):1989-1998. DOI:10.1021/acs.jmedchem.8b01541 |
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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