| Identification | Back Directory | [Name]
N-(Amino-PEG3)-N-bis(PEG4-Boc) | [CAS]
2353409-57-9 | [Synonyms]
N-(Amino-PEG3)-N-bis(PEG4-Boc)
N-(Amino-PEG3)-N-bis(PEG4-t-butyl ester) | [Molecular Formula]
C38H76N2O15 | [MDL Number]
MFCD31811448 | [MOL File]
2353409-57-9.mol | [Molecular Weight]
801.01 |
| Chemical Properties | Back Directory | [Boiling point ]
743.7±55.0 °C(Predicted) | [density ]
1.076±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [pka]
8.74±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
N-(Amino-PEG3)-N-bis(PEG4-t-butyl ester) is a PEG linker that can easily react with activated NHS esters or carboxylic acid in the presence of EDC or HATU. The t-butyl group can be deprotected under acidic conditions. | [Uses]
N-(Amino-PEG3)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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