ChemicalBook--->CAS DataBase List--->2359650-19-2

2359650-19-2

Request For Quotation
2359650-19-2 Structure

2359650-19-2 Structure
IdentificationBack Directory
[Name]

17,19-Metheno-1H,5H-cyclopent[5,6][1,4]oxazino[3,4-i]pyrazolo[4,3-f]pyrido[3,2-l][1,4,8,10]oxatriazacyclotridecin-14(11H)-one, 7-fluoro-2,3,3a,12,13,20a-hexahydro-11-methyl-, (3aS,11R,20aR)-
[CAS]

2359650-19-2
[Synonyms]

17,19-Metheno-1H,5H-cyclopent[5,6][1,4]oxazino[3,4-i]pyrazolo[4,3-f]pyrido[3,2-l][1,4,8,10]oxatriazacyclotridecin-14(11H)-one, 7-fluoro-2,3,3a,12,13,20a-hexahydro-11-methyl-, (3aS,11R,20aR)-
[Molecular Formula]

C21H21FN6O3
[MOL File]

2359650-19-2.mol
[Molecular Weight]

424.43
Chemical PropertiesBack Directory
[density ]

1.68±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 2 mg/mL (4.71 mM);Ethanol: Insoluble
[form ]

Solid
[pka]

10.44±0.40(Predicted)
[color ]

White to off-white
[Water Solubility ]

Water: Insoluble
[InChIKey]

BYYQDEOVMILBQT-XFBWCDHKSA-N
[SMILES]

O1C2=NC=C(F)C=C2CN2[C@@]3([H])CCC[C@@]3([H])OC3=CN4C(N=C23)=C(C=N4)C(=O)NC[C@H]1C
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319
[Precautionary statements ]

P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330
Hazard InformationBack Directory
[Uses]

Enbezotinib (enantiomer) (Compound 44) is the enantiomer form of Enbezotinib (HY-145565). Enbezotinib is an inhibitor of RET[1].
[Biological Activity]

TPX-0046 is a novel RET/SRC inhibitor with a mean IC50 of 17 nM for RETG810R in Ba/F3 cell proliferation assay. TPX-0046 is a new type of RET/SRC inhibitor and potent against a range of RET fusions and mutations including solvent front mutations (SFMs)-mediated resistance. In Ba/F3 RET engineered cells with SFMs proliferation test, the average IC50 is 1-17 nM.[2] TPX-0046 demonstrates marked anti-tumor efficacy in vivo in multiple RET-driven cancer cell-derived and patient-derived xenograft tumor models.[2]
[storage]

Store at -20°C
[References]

[1] Noura J Choudhury, Alexander Drilon. Transl Lung Cancer Res. 2020 Dec;9(6):2571-2580. [2] Alexander E Drilon, et al. Journal of Clinical. 2020 May; 38(15_suppl): 3616.
Spectrum DetailBack Directory
[Spectrum Detail]

17,19-Metheno-1H,5H-cyclopent[5,6][1,4]oxazino[3,4-i]pyrazolo[4,3-f]pyrido[3,2-l][1,4,8,10]oxatriazacyclotridecin-14(11H)-one, 7-fluoro-2,3,3a,12,13,20a-hexahydro-11-methyl-, (3aS,11R,20aR)-(2359650-19-2)1HNMR
2359650-19-2 suppliers list
Company Name: Nanjing Chemlin Chemical Co., Ltd  
Telephone: 025-83697070 13770331960
Website: www.echemlin.cn
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Telephone: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: Shanghai Chaolan Chemical Technology Center  
Telephone: QQ：65489617 13301690235
Website: www.atkchemical.com/
Company Name: Chuzhou KeMail Chemical Technology Co., Ltd  
Telephone: 0550-5196001 15000891977
Website: https://www.chemicalbook.com/ShowSupplierProductsList19947/0_EN.htm
Company Name: Zhejiang J&C Biological Technology Co.,Limited  
Telephone: +1-2135480471
Website: https://www.sarms4muscle.com
Company Name: Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd  
Telephone: 15317229551
Website: https://www.ureiko.com
Company Name: Suzhou Chenrui Biotechnology Co. LTD  
Telephone: 17625585511
Website: www.chemicalbook.com/ShowSupplierProductsList660257/0_EN.htm
Company Name: ShangHai ChuanQian Chemcial Technique Centre  
Telephone: 15869524721
Website: www.chemicalbook.com/ShowSupplierProductsList68594/0_EN.htm
Company Name: Zhengzhou convergence chemical co., LTD  
Telephone: 037155153829 18003835034
Website: https://www.chemicalbook.com/supplier/24021783/
Company Name: Nantong Hi-Future Biotechnology Co., Ltd  
Telephone: +86-0513; 18051384581
Website: https://www.chemhifuture.com/
Company Name: Jiangsu Nanchuang Chemical and Life Health Research Institute Co., Ltd.  
Telephone: 15720605021
Website: http://www.jsnchem.com/
Company Name: Bide Pharmatech Ltd.  
Telephone: 400-1647117 13681763483
Website: https://www.bidepharm.com/
Company Name: TargetMol Chemicals Inc.  
Telephone: 4008200310 15002144251
Website: https://www.targetmol.cn/
Company Name: Shanghai Tachizaki Biomedical Research Center  
Telephone: 18014399201
Website: http://www.chemlab-tachizaki.com/
Company Name: PharmaBlock Sciences (Nanjing), Inc.  
Telephone: 4000255188
Website: www.pharmablock.com/
Company Name: Nanjing Shizhou Biology Technology Co.,Ltd  
Telephone: 025-85560043 15850508050
Website: http://www.synzest.com
Company Name: RD International Technology Co., Limited  
Telephone: 18024082417
Website: www.ruidiresearch.com
Company Name: Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd.  
Telephone: 025-66061636 19370895928
Website: www.aikonchem.com/
Tags:2359650-19-2 Related Product Information
1802220-02-5 2648641-36-3 2271119-26-5 2359650-19-2 2700265-62-7