ChemicalBook--->CAS DataBase List--->2361055-48-1

2361055-48-1

2361055-48-1 Structure

2361055-48-1 Structure
IdentificationBack Directory
[Name]

Mipasetamab
[CAS]

2361055-48-1
[Synonyms]

Mipasetamab
Research Grade Mipasetamab (DHD89503)
Chemical PropertiesBack Directory
[form ]

Liquid
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Uses]

Mipasetamab is an IgG1κ antibody targeting to AXL, a tyrosine kinase receptor and an TAM Receptor. Mipasetamab involves in synthesis of ADCT-601 (Mipasetamab uzoptirine), an AXL-targeted antibody-drug conjugate (ADC). ADCT-601 has anti-tumor activity[1].
[in vivo]

ADCT-601 (3 mg/kg, 6 mg/kg; i.v.; single dose) is safety and tolerability in non-tumor-bearing male Sprague-Dawley rats[1].
ADCT-601 (1 mg/kg; i.v.; once daily for 60 days) shows potent and sustained antitumor activity for mouse in both MDA-MB-231 TNBC xenograft model and SN12C renal cancer xenograft model[1].
ADCT-601 (0.075, 0.15, or 0.3 mg/kg; i.v.; once daily for 45 days) also dose-dependently in a pancreatic cancer PDX model (PAXF1657) with heterogeneous AXL expression[1].

Animal Model:Mouse model with SN12C renal cancer xenograft or MDA-MB-231 TNBC xenograft[1]
Dosage:0.3, 0.6, and 1 mg/kg
Administration:Intravenous injection; once daily for 60 days
Result:Significantly inhibited the growth of tumor volume in vivo in mouse.
[IC 50]

Axl
[References]

[1] Zammarchi F, et al. Preclinical Development of ADCT-601, a Novel Pyrrolobenzodiazepine Dimer-based Antibody-drug Conjugate Targeting AXL-expressing Cancers. Mol Cancer Ther. 2022 Apr 1;21(4):582-593. DOI:10.1158/1535-7163.MCT-21-0715
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