| Identification | Back Directory | [Name]
BSJ-03-123 | [CAS]
2361493-16-3 | [Synonyms]
BSJ-03-123
Acetamide, N-[2-[2-[2-[2-[4-[6-[(6-acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]ethoxy]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- | [Molecular Formula]
C47H56N10O11 | [MDL Number]
MFCD31813815 | [MOL File]
2361493-16-3.mol | [Molecular Weight]
937.01 |
| Chemical Properties | Back Directory | [density ]
1.375±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 100 mg/mL (106.72 mM; ultrasonic and adjust pH to 3 with HCl) | [form ]
Solid | [pka]
10.68±0.40(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
BSJ-03-123 is a PROTAC connected by ligands for Cereblon and CDK as a potent and novel CDK6-selective small-molecule degrader. | [IC 50]
CDK6; Cereblon | [storage]
4°C, protect from light | [References]
[1] Brand M, et al. Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML. Cell Chem Biol. 2019 Feb 21;26(2):300-306.e9. DOI:10.1016/j.chembiol.2018.11.006 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
|