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2361497-72-3

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2361497-72-3 Structure

2361497-72-3 Structure

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[Name] INDEX NAME NOT YET ASSIGNED
[CAS] 2361497-72-3
[Synonyms] CPL207280 Benzenepropanoic acid, 4-[(2,3-dimethyl-2-buten-1-yl)oxy]-β-1-propyn-1-yl-, (βS)-
[Molecular Formula] C18H22O3
[MOL File] 2361497-72-3.mol
[Molecular Weight] 286.37

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[Boiling point ] 451.7±45.0 °C(Predicted)
[density ] 1.073±0.06 g/cm3(Predicted)
[pka] 4.21±0.10(Predicted)

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[Uses] CPL207280 is an orally active GPR40/FFA1 agonist with an antidiabetic effect. CPL207280 can effectively enhance glucose-stimulated insulin secretion and improve glucose tolerance in MIN6 pancreatic β-cells as well as in healthy Wistar Han rats and diabetic rat models. CPL207280 can be used for the research of type 2 diabetes[1][2].
[in vivo] PL207280 (10 mg/kg; p.o.; single dose) exhibits hypoglycemic effects in Wistar Han rats, with (3 mg/kg; p.o.; single dose) pharmacokinetic parameters of C_max, T_max, and T_1/2 being 1699 ng/mL, 1 h, and 1.41 h, respectively^[1].
[References] [1] Mach M, et al. Discovery and development of CPL207280 as new GPR40/FFA1 agonist. Eur J Med Chem. 2021;226:113810. DOI:10.1016/j.ejmech.2021.113810 [2] Bazydlo-Guzenda K, et al. CPL207280-a novel GPR40/FFA1-specific agonist shows a favorable safety profile and exerts anti-diabetic effects in type 2 diabetic animals[J]. Molecular Pharmacology, 2021.

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