| Chemical Properties | Back Directory | [density ]
1.53±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 250 mg/mL (366.03 mM) | [form ]
Solid | [pka]
10.39±0.70(Predicted) | [color ]
White to off-white | [InChIKey]
HZPYSAHDRSBARR-QPJJXVBHSA-N | [SMILES]
O=C(C1=NNC=C1NC(C2=C(Cl)C=C(Cl)C=C2Cl)=O)NC3CCN(S(=O)(C4=CC=CC(NC(/C=C/CN(C)C)=O)=C4)=O)CC3 |
| Hazard Information | Back Directory | [Uses]
FMF-04-159-2 is a covalent CDK14 inhibitor. FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively[1]. | [Biological Activity]
FMF-04-159-2 is a specific and potent covalent inhibitor Cyclin-dependent kinase 14 (CDK14) in cells th at targets CDK14 at C218. FMF-04-159-2 reversibly inhibits CDK2CDK10and other TAIRE kinases (CDK15CDK16CDK17and CDK18) with comparable potency to each other. It exhibits mild antiproliferative effects. | [IC 50]
CDK14/Cyclin Y: 39.6 nM (IC50, in NanoBRET assay); CDK2: 256 nM (IC50, in NanoBRET assay) | [storage]
Store at -20°C | [References]
[1] Ferguson FM, et al. Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. Cell Chem Biol. 2019 Mar 11. pii: S2451-9456(19)30070-4. DOI:10.1016/j.chembiol.2019.02.015 |
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
|