| Identification | Back Directory | [Name]
5-endo-BCN-pentanoic acid | [CAS]
2364591-80-8 | [Synonyms]
endo-BCN-pentanoic acid
5-endo-BCN-pentanoic acid | [Molecular Formula]
C16H23NO4 | [MDL Number]
MFCD32069515 | [MOL File]
2364591-80-8.mol | [Molecular Weight]
293.36 |
| Chemical Properties | Back Directory | [Boiling point ]
495.2±28.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Oil | [pka]
4.72±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
endo-BCN-pentanoic acid is a click chemistry reagent containing a BCN group and a terminal carboxylic acid. The BCN group can react with azide-tagged compounds or biomolecules. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
5-endo-BCN-pentanoic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 5-endo-BCN-pentanoic acid is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
Alkyl-Chain | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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