| Identification | Back Directory | [Name]
Complement C5-IN-1 | [CAS]
2365402-67-9 | [Synonyms]
Complement C5-IN-1
C5 complement inhibitor 7
COMPOUND C5-IN-1 (COMPOUND 7) | [Molecular Formula]
C24H32N2O6 | [MDL Number]
MFCD32174288 | [MOL File]
2365402-67-9.mol | [Molecular Weight]
444.52 |
| Chemical Properties | Back Directory | [Boiling point ]
576.9±50.0 °C(Predicted) | [density ]
1.179±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 100 mg/mL (224.96 mM) | [form ]
Solid | [pka]
3.92±0.36(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Complement C5-IN-1 is the first potent inhibitor of C5 complement protein. | [Uses]
Complement C5-IN-1 (Compound 7) is a small-molecule inhibitor of complement component 5 protein (C5). Complement C5-IN-1 interacts with C5 to prevent its cleavage by the C5 convertase and blocks zymosan-induced the membrane-attack complex (MAC) deposition in 50% human whole blood with an IC50 of 0.77?μM[1]. | [storage]
Store at -20°C | [References]
[1] Jendza K, et al. A small-molecule inhibitor of C5 complement protein. Nat Chem Biol. 2019 Jul;15(7):666-668. DOI:10.1038/s41589-019-0303-9 |
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