| Identification | Back Directory | [Name]
3H-Xanthen-3-one, 9-[4-[[bis[2-[[2-(ethylthio)ethyl]thio]ethyl]amino]methyl]-2-(trifluoromethyl)phenyl]-6-(1-piperidinyl)- | [CAS]
2365532-64-3 | [Synonyms]
3H-Xanthen-3-one, 9-[4-[[bis[2-[[2-(ethylthio)ethyl]thio]ethyl]amino]methyl]-2-(trifluoromethyl)phenyl]-6-(1-piperidinyl)- | [Molecular Formula]
C38H47F3N2O2S4 | [MOL File]
2365532-64-3.mol | [Molecular Weight]
749.05 |
| Chemical Properties | Back Directory | [Boiling point ]
848.7±65.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
6.83±0.50(Predicted) | [color ]
Brown to reddish brown |
| Hazard Information | Back Directory | [Description]
Copper probe CF4 is a fluorescent copper probe. | [Uses]
Copper Fluor-4 (CF4) is a Cu+-specific fluorescent probe based on a rhodol dye scaffold. Copper Fluor-4 has high copper selectivity with a Kd value of 2.9×10?13 M, particularly over zinc and iron, as well as abundant cellular alkali and alkaline earth metals. Copper Fluor-4 is stable in a physiologically relevant pH regime between 6 and 8 (wavelengths of 415 nm for excitation and 660 nm for emission)[1][2][3]. | [in vivo]
Copper Fluor-4 (2 μM, 24 h) can be used to assess changes in labile copper distributions in small living organisms such as zebrafish embryos[1].
Copper Fluor-4 (10 μM, 3 h) can be used to assess labile Cu levels with a Kd value of 2.9×10?13 M for a 1:1 copper:probe stoichiometry that is well-matched to monitor labile Cu pools by reversible Cu binding without depleting the total Cu store in worms[2].
| [References]
[1] Xiao T, et al. Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system. Nat Chem Biol. 2018 Jul;14(7):655-663. DOI:10.1038/s41589-018-0062-z
[2] Weishaupt AK, et al. Dysfunction in atox-1 and ceruloplasmin alters labile Cu levels and consequently Cu homeostasis in C. elegans. Front Mol Biosci. 2024 Feb 8;11:1354627. DOI:10.3389/fmolb.2024.1354627
[3] Chakraborty K, et al. Copper dependent ERK1/2 phosphorylation is essential for the viability of neurons and not glia. Metallomics. 2022 Apr 1;14(4):mfac005. DOI:10.1093/mtomcs/mfac005 |
|
|