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2366264-18-6

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2366264-18-6 Structure

2366264-18-6 Structure
IdentificationBack Directory
[Name]

2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)-
[CAS]

2366264-18-6
[Synonyms]

JNK3 inhibitor-2
2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)-
[Molecular Formula]

C20H14N2O2
[MOL File]

2366264-18-6.mol
[Molecular Weight]

314.34
Chemical PropertiesBack Directory
[Boiling point ]

557.4±50.0 °C(Predicted)
[density ]

1.334±0.06 g/cm3(Predicted)
[pka]

15.06±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

JNK3 inhibitor-2 is a potent and selective JNK3 inhibitor with IC50 values of >100, >100, 0.25 μM for JNK1, JNK2, JNK3, respectively. JNK3 inhibitor-2 shows DDR1 and EGFR (T790M, L858R) inhibition[1].
[IC 50]

JNK1: >100 μM (IC50); JNK2: >100 μM (IC50); JNK3: 0.25 μM (IC50)
[References]

[1] Dou X, et al. Rational modification, synthesis and biological evaluation of 3,4-dihydroquinoxalin-2(1H)-one derivatives as potent and selective c-Jun N-terminal kinase 3 (JNK3) inhibitors. Eur J Med Chem. 2020 Sep 1;201:112445. DOI:10.1016/j.ejmech.2020.112445
2366264-18-6 suppliers list
Company Name: Tianjin Kailiqi Biotechnology Co., Ltd.  
Telephone: 15076683720
Website: http://www.cw-bio.com
Company Name: Jinan Jiuli Biotechnology Co. , Ltd.  
Telephone: 15865264761
Website: www.chemicalbook.com/ShowSupplierProductsList89365/0_EN.htm
Company Name: TargetMol Chemicals Inc.  
Telephone: 4008200310 15002144251
Website: https://www.targetmol.cn/
Company Name: Shandong Dayou Pharmaceutical Research and Development Co., Ltd.  
Telephone: hanfangpharma@126.com 15165037910
Website: hanfangpharma@126.com
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