| Identification | Back Directory | [Name]
3-Pyridazinecarboxamide, 6-(1H-imidazol-1-yl)-N-[2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]- | [CAS]
2375419-35-3 | [Synonyms]
3-Pyridazinecarboxamide, 6-(1H-imidazol-1-yl)-N-[2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]- | [Molecular Formula]
C17H11F6N5O2 | [MOL File]
2375419-35-3.mol | [Molecular Weight]
431.29 |
| Chemical Properties | Back Directory | [Boiling point ]
523.3±50.0 °C(Predicted) | [density ]
1.55±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
8.83±0.20(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
STING agonist-21 (compound 1) is a STING agonist, with an EC50 of 592.8 nM. STING agonist-21 can be used for cancer research[1]. | [Biological Activity]
SR-301 is an orally bioavailable analog of the selective STING agonist SR-717. SR-301 shows higher potency than SR-717 by THP1-based ISRE reporter assay (EC50 = 0.6 vs. 2.1 μMrespectively) and shows good antitumor efficacy when administered orally in a murine B16.F10 melanoma tumor model in vivo (15 mg/kg/day p.o.). | [References]
[1] Luke L. LAIRSON, et al. Agonists of stimulator of interferon genes sting. Patent, WO2019165032A1 |
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Merck KGaA
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21-20338288 |
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Biorbyt Ltd.
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http://www.biorbyt.com |
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