| Identification | Back Directory | [Name]
RC32 | [CAS]
2375555-66-9 | [Synonyms]
RC32
FKBP12 PROTAC RC32 | [Molecular Formula]
C75H107N7O20 | [MDL Number]
MFCD32858275 | [Molecular Weight]
1426.69 |
| Hazard Information | Back Directory | [Uses]
FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology. FKBP12 PROTAC RC32 contains conjugation of Rapamycin (HY-10219) and a ligand for an Cereblon E3 ubiquitin ligase (Pomalidomide; HY-10984)[1]. | [in vivo]
RC32 (RC32; i.p.; 30 mg/kg; twice a day; 1 day) degrades the FKBP12 protein in most of the organs of treated mice, except for the brain after only 1 day of treatment in mice[1].
RC32 (orally; 60 mg/kg; twice a day; for 1 day) significantly degrades FKBP12 in mice[1].
RC32 (i.p.; 8 mg/kg; twice a day; for 2 days) efficiently degrades the FKBP12 protein in most of the organs examined in Bama pigs (20 kg) [1].
RC32 (i.p.; 8 mg/kg; twice a day; for 3 days) efficiently degrades FKBP12 in the heart, liver, kidney, spleen, lung, and stomach of rhesus monkeys[1].
| Animal Model: | Male and female mice[1] | | Dosage: | 30?mg/kg | | Administration: | IP; twice a day; 1 day | | Result: | Degraded the FKBP12 protein in most of the organs of treated mice after only 1 day of treatment.
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| [IC 50]
Cereblon | [References]
[1] A chemical approach for global protein knockdown from mice to non-human primates. Cell Discov. 2019 Feb 5;5:10. DOI:10.1038/s41421-018-0079-1 |
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